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42 However, direct injection can be less efficient because of limited diffusion between the cerebrospinal and extracellular fluids

Its mechanism of action is primarily mediated by its role as a substrate for NAD + -dependent enzymes such as the sirtuin family (SIRT1-7), poly(ADP-ribose) polymerases (PARPs), and certain ectoenzymes like CD38 and CD157

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The result agreed with a previous study that demonstrated that administration of ginger essential oil (100, 200, and 400 mg/kg) to sheep red blood cell-immunized mice recovered the immune response in CPA-induced immunosuppressed mice compared with the control ( Oncorhynchus mykiss )