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Selenocysteine (Sec) is the substitution of Se for sulfur from cysteine, which can enhance the resistance of GPX4 to irreversible peroxidation and prevent hydroperoxide-induced ferroptosis [13, 31]

Supplementing with glutathione may help replenish its levels and support overall health

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By inhibiting these associated pathways through PAR2 inhibition, the proliferation of chemoresistance cells is reduced and cancer cell death is more abundant (143)

Similarly, conjugation of a new cytotoxic platinum (IV) prodrug (C8Pt(IV)) with cetuximab (Cet-C8Pt(IV)) also showed excellent tumour targeting in cutaneous squamous cell carcinoma (Fig

Eisenberg T, Knauer H, Schauer A, Bttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, Fussi H, Deszcz L, Hartl R, Schraml E, Criollo A, Megalou E, Weiskopf D, Laun P, Heeren G, Breitenbach M, Grubeck-Loebenstein B, Herker E, Fahrenkrog B, Frhlich KU, Sinner F, Tavernarakis N, Minois N, Kroemer G, Madeo F (2009) Induction of autophagy by spermidine promotes longevity