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We then compared the effects of the two treatments on these pathological processes

Transcobalamin receptor (TCblR/CD320) polymorphisms may also impact on serum holoTC concentrations

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doi:10.1016/s0091-6749(03)00010-1 16 Garcia-MaurioSGonzalez-HabaMGCalvoJRRafii-El-IdrissiMSanchez-MargaletVGobernaRet al

2 Neurobiological basis of nicotine addiction The rewarding mechanism of nicotine addiction exhibits complex biphasic regulatory characteristics, where the dynamic equilibrium between positive reinforcement (such as euphoria) and negative regulation (such as aversive reactions) constitutes the neurobiological basis for the formation of addictive behaviors