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however, its specificity remains limited [16]

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PMID: 38856181)

[DOI] [PubMed] [Google Scholar] 128

As the sole sirtuin family member predominantly localized to the nucleolus, SIRT7 positively regulates RNA Polymerase I (Pol I) transcription, 309,310 which is crucial for alleviating nucleolar stress and has been implicated in preventing premature aging

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