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This study was supported by the National Natural Science Foundation of China (Nos

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Accordingly, the authors proposed a model in which H 2 S administration improves the NAD + /NADH ratio and thus SIRT3 activity, leading to a myocardial substrate oxidation pattern that more closely resembles the physiologic myocardial substrate preference, thereby increasing the efficiency of ATP regeneration [80]

6 Outlook Using proteomics analysis, validation experiments, and stain-free total protein technology, this study provided a reference for future studies on the local pathological mechanisms of GA and offered predictive directions for its pathological changes

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