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The immunomodulatory functions of butyrate

Studies suggest it activates lipolysis the process of breaking down stored fat and inhibits lipogenesis, which is the formation of new fat cells

Making healthier eating choices

The conversion of macrophages from a pro-inflammatory to an anti-inflammatory phenotype is also impeded, leading to abnormal chronic inflammation in various organs, such as skin tissue wounds and pancreatic islets, resulting in their tissue damage and dysfunction (138, 139)

Abnormal activation of MAIT cells may lead to excessive production of inflammatory mediators, further exacerbating liver inflammation [115]

The systematic exploration of these NANT pathways is critical for addressing gaps in AD drug development, particularly the need for biomarkers that can monitor treatment response and index clinical severity beyond A-targeting therapies