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The systems were initially neutralized with Na+ counterions via the tleap module in AMBER22 to balance electrostatic charges

P140, a selectively autophagy-targeting peptide, rectifies autophagic dysfunction in autoimmune and inflammatory disorders that rely on CMA mainly

A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells

Given the significant improvement seen in CKD progression, SGLT2 inhibitors are now recommended for CKD with albuminuria regardless of the presence of diabetes, as it has been shown to slow estimated glomerular filtration rate (eGFR) decline, delay the onset of end stage kidney disease (ESKD), and decrease all-cause mortality (148)

Plasmids, reagents and antibodies Plasmids used in this study are described in Supplementary Table 4

Moreover, the improvement of pharmacological effect in disease models in vivo by prodrug approach was shown only for the prodrug of 7-chlorokynurenic acid (133, 134) and ibuprofen prodrugs (145) when compared to parent drug administration