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It is not metabolized by hepatic cytochrome P450 (CYP) enzymes

5 Signs and Symptoms Symptoms of lung cancer include chest discomfort or pain, persistent cough, trouble breathing, wheezing, bloody sputum, hoarseness, loss of appetite, unexplained weight loss, fatigue, trouble swallowing, and swelling in the face and/or veins in the neck (NCI 2013c)

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4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease

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People who are pregnant and breastfeeding should get 600 and 500 mcg, respectively