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Table 4 Associations between genetic polymorphisms and plasma MTX level at 48 h

Consult your healthcare provider before use if pregnant or nursing

Food and Drug Administration (FDA) has approved various small-molecule drugs for cancer chemotherapy, including doxorubicin (DOX), camptothecin (CPT) and its derivative SN-38, gemcitabine (GEM), paclitaxel (PTX), 5-fluorodeoxyuridine (FDU), cisplatin, carboplatin, and oxaliplatin (Figure 1) (Liu et al., 2023

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Free Radic Biol Med 52(5):92836 Ding YW, Zhao GJ, Li XL, Hong GL, Li MF, Qiu QM et al (2016) SIRT1 exerts protective effects against paraquat-inducedinjury in mouse type II alveolar epithelial cellsby deacetylating NRF2 in vitro

They found that pituitary T3 and TSH levels remained unchanged while the peripheral tissues were significantly reduced