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Occasional mild injection-site reactions (transient redness or stinging) may occur with subcutaneous administration

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The rationale for combining these two agents is deeply rooted in the complementary biology described above

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However, local circuit effects must be considered when deciphering pre- versus postsynaptic localization of opioid receptor actions, as postsynaptic hyperpolarization can reduce local circuit neurotransmitter release (Figures 2A,B)