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NP accumulation is restricted in cases of larger tumors because of their heterogeneous vasculature

Overexpression of miR-506 in cholangiocytes leads to multiple PBC-like features, including impaired cell proliferation and adhesion, sensitization to bile acid-induced apoptosis, impaired energy metabolism, PDC-E2 overexpression and mislocation into the plasma membrane, and immune activation

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J Proteome Res 13(12):57155723