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Other studies have shown that TRIM46 enhances lipid peroxidation and ferroptosis in HRCECs stimulated by high glucose through promoting GPX4 ubiquitination (178)

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Differences in results are due to a combination of factors including ascorbic acid-related concerns (doses, administration routes, plasmatic levels, metabolites recording, and source), cancer characteristics (specific mutations present, type and grade of cancer, received conventional anti-cancer therapy), and individual characteristics (diet, behaviors, genetics, transporters)

These genes were then compared with the meta-modules to analyze their number and distribution in each module

In the setting of chronic ROS accumulation, B1 cells may experience impaired autophagy leading to inhibited homeostatic proliferation or death