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With this respect the development of novel therapeutic approaches targeting ROS will require to identify and dampen the main sources of deleterious ROS relevant for a specific disease, without altering the vital physiological sources of ROS and their downstream signaling pathways

Olsson, A., Lind, L., Thornell, L

By lowering intracellular ROS and inhibiting NF-B-dependent transcriptional priming of NLRP3, Nrf2 activity functionally lowers inflammasome formation in sterile neuroinflammatory conditions such as PD

They require clinic visits, they cost more, and they don't offer a meaningful advantage over high-dose oral supplementation when absorption isn't the problem

Patients undergoing bariatric surgery (BS) from 9/30/2008 to 9/30/2020 (sleeve gastrectomy (LSG) or gastric bypass (RYGB)) were risk-set matched 4:1 to MOVE

doi: 10.1007/s11883-012-0280-x