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Y.KyriakopoulosA.NinnemannO.et al (2003)

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As an adjunct to fluid and electrolyte replacement therapy and the use of other drugs and procedures in the treatment of hypovolemic and septic shock, low cardiac output (hypoperfusion) states, congestive heart failure, and cardiogenic shock

The cellular adaptations initiated during the active phase continue to develop during the rest period

This indicates that the beneficial clinical effects observed after repeated dosing can not be ascribed to an accumulation of NAC in plasma