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In research models, MOTS-c behaves similarly to exercise at the cellular level activating AMPK, promoting glucose uptake, and triggering mitochondrial biogenesis

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They interact with G-protein-coupled receptors, ion channels, or internal cellular machinery to exert diverse effects, including hormonal stimulation, angiogenesis, mitochondrial regulation, or immune modulation

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2) FOXO4-DRI was shown to improve spermatogenesis in aged mice by decreasing the secretion of senescence-associated secretory phenotype