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Baseline scan before starting, follow-up at 6-8 weeks, and final assessment at protocol completion enable accurate fat loss quantification

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Studies reveal enhanced fatty acid oxidation, increased energy expenditure, and improved metabolic efficiency through direct NNMT inhibition, positioning it as breakthrough tool for investigating obesity mechanisms without appetite suppression

This study design variety strengthens the overall safety assessment by capturing both acute and chronic exposure patterns

In this study, significant positive correlations were observed between tryptophan, tyrosine, and xanthine abundances in the EWAT and the relative abundance of Parasutterella in the cecal microbiome (Supplementary Table S5, outliers removed)

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