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I.ThompsonW.et al (2019)

Pathophysiology of hypertension in the absence of nitric oxide/cyclic GMP signaling

Unspecific therapies such as apoptosis inhibitors, autophagy promoters or hormone treatment might bring universal effects to other cell biological processes and cause unpredictable consequences, which are not suitable for clinical application

Chemotherapeutic agents that induce oxidative stress and produce heightened cellular levels of ROS therefore have the potential to selectively induce apoptosis in Akt-activated cancer cells