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Future studies examining SNAT expression patterns, transport activity, and regulatory signaling under Pb exposure could provide valuable insights into additional mechanisms contributing to excitotoxicity and cognitive impairment

BM-MSCs or BM-MSCs-exosome co-treatment caused anti-apoptotic impacts via a meaningful reduction in Bax/Bcl2 ratio and a rise in the expression of mitochondrial mitophagy genes, including Parkin RBR E3 Ubiquitin Protein Ligase ( Parkin ), phosphatase and tensin homolog (PTEN)-induced putative kinase 1 ( PINK1 ), unc-51 like autophagy activating kinase 1 ( ULK1 ), B-cell lymphoma 2/adenovirus E1B 19 kDa protein-interacting protein 3 ( BNIP3L ), autophagy related gene ( ATG5 ), ATG7 and ATG12

Cuprous ion (Cu + ) is able to react with O 2 and form a peroxide bridge between heme groups and cupric ion (Cu 2+ )

A low concentration of vitamin E is frequently observed in cerebrospinal fluid (CSF)

The study of succinate as an oncometabolite has only recently begun, and more research needs to be conducted to completely understand its tumorigenic properties

Feb 18 2021;10(4)doi:10.3390/jcm10040829 Wekker V, van Dammen L, Koning A, et al