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Ergolide also enhances the anti-tumor effect of vincristine

We consider whether current disease-modifying therapies for relapsingremitting MS meet the criteria for successful therapeutics in PMS and suggest that the evidence favours the early introduction of sphingosine 1-phosphate receptor modulators

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Therapeutic translation bottlenecks are prominent: compounds effective in preclinical studies (e.g., andrographolide) often fail in human trials, as animal models cannot replicate patients individual differences and complex pathology (124)

Generally speaking, bracket prescriptions vary significantly from one patient to the nextand even from the right to left side of the same patient

74 OgawaK.MoritoH.HasegawaA.MiyagawaF.KobayashiN.WatanabeH.et al (2014)