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1 It is therefore usually administered with a DDI and with a catecho Strengths and limitations of levodopa Although levodopa has been a major success story for the management of PD, it does have some limitations, such as the development of dopa-related response fluctuations (both motor and non-motor) and drug-induced dyskinesias

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It is naturally found in human plasma, saliva, and urine

In fact, if the dosing history is unknown or incomplete, a drug concentration measurement loses all predictive value

As consumption forms a very necessary metric for calculating AD, disposable income is also an important metric for AD, an increase in DI increases consumption which increases AD