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Research found that a decreased network response to stimulation in both excitatory and inhibitory circuits of the sensory cortex of Nlgn4 knock-out animals as compared to wild-type controls, and a decreased excitation-inhibition ratio, suggesting that Nlgn4 is involved in the regulation of excitatory and inhibitory circuits and contributes to a balanced circuit response to stimulation (88).Another study reports, Nlgn4 knockout disrupts GABAergic synaptic transmission and oscillatory activity in the hippocampus and causes deficits in social interaction

3 were initially assigned a role in maintaining GSH homeostasis ( Arabidopsis , mirroring the function of mammalian CHAC2 (Vernoux et al., 2000)

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SSR504734 in another study also showed anticonvulsive effects in the PTZ model in a single-dose regimen, although the effects were not consistent across all models tested (Gapiska et al