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Dephosphorylation of fructose-1,6-bisphosphate back to fructose-6-phosphate does not occur, considering that in most cancers the expression of fructose-1,6-bisphosphatase is strongly diminished 117

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Specifically, patients participating in this regimen demonstrated significant improvements in walking capacity, suggesting that structured physical activity programs can play a crucial role in optimizing cancer treatment, particularly in improving functional recovery and reducing fatigue during and post-treatment [188]