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Main histological changes of ATN are: merging and loss of tubular epithelial cells, focal dilatation of proximal tubules, partial occlusion of tubular lumens by cellular debris and multiple mitoses
Why Glutathione Is iBlushs Hero Ingredient When we designed iBlush, glutathione was a no-brainer
Toxicological evaluation Levels that cause no toxic effect Mouse: 80 ppm, equivalent to 12 mg/kg bw per day (toxicity in a 78-week study of toxicity and carcinogenicity) Rat: 40 ppm, equivalent to 2 mg/kg bw per day (toxicity in two 2-year studies of toxicity and carcinogenicity) 160 mg/kg bw per day (maternal and developmental toxicity in a study of developmental toxicity) 10 mg/kg bw per day (parental and reproductive toxicity in a two-generation study of reproductive toxicity) Rabbit: 20 mg/kg bw per day (maternal and developmental toxicity in a study of developmental toxicity) Dog: 100 ppm, equivalent to 2.5 mg/kg bw per day (toxicity in a 90-day study of toxicity) Estimate of acceptable daily intake for humans 0-0.02 mg/kg bw Estimate of acute reference dose 0.02 mg/kg bw Studies that would provide information useful for continued evaluation of the compound Further observations in humans Toxicological end-points relevant for setting guidance values for dietary and non-dietary exposure to dimethipin Absorption, distribution, excretion and metabolism in mammals Rate and extent of oral absorption 69% within 24 h, rats Dermal absorption Low dermal penetration, rabbits Distribution Widely distributed, rats Potential for accumulation No evidence of accumulation Rate and extent of excretion 89% within 48 h mainly via urine Metabolism in animals Parent 5000 mg/kg bw Rat, LC 50 , inhalation 0.88 mg/L, 4 h (female) and 1.5 mg/L, 4 h (males) Rabbit, dermal irritation Not irritating Rabbit, ocular irritation Severely irritating Guinea-pig, dermal sensitization Weakly sensitizing Short-term toxicity Target/critical effect Liver: hepatotoxicity, hepatic hypertrophy, rats Lowest relevant oral NOAEL 2 mg/kg bw per day, rats Lowest relevant dermal NOAEL 1000 mg/kg bw per day (highest dose tested), rats Lowest relevant inhalation NOAEL Not determined Long-term toxicity and carcinogenicity Target/critical effect Rat liver: increased weight, liver enzymes, bile-duct hyperplasia
Brock P, Sevigny M, Liyanarachchi S, Comiskey DF, Li W, Saarinen S, et al
In a cellular model, steatosis was induced in Hep2G cells by exposing them to oleic acid and co-culturing them with vitamin C, N-acetylcysteine, and ASTX
