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It was observed that berberine attenuates LPS-induced cognitive dysfunction through regulation of the SIRT1/NF-B axis in mice (Docrat et al

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This makes the monotherapy regression coefficient less robust than the combination finding Heterogeneity in protocols: The included studies used different needle depths (0.52.5 mm), frequencies (weekly to monthly), devices (dermaroller, dermapen, fractional radiofrequency), and treatment durations, which adds variability to the pooled analysis Primarily male populations: Most included studies focused on male androgenetic alopecia

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