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Whether the fragment reproduces any clinically meaningful part of the parent peptides biology in humans is, at present, an open question rather than an established fact

In 2020, Horsfall et al

Polley: Some providers take hard lines like, My patient smokes cannabis (marijuana) and they have a positive urine drug screen (UDS), so I do not prescribe stimulants. I try to have a more nuanced approach

No mention of consent or discussion of treatment

It increases or decreases appropriately according to age and symptoms

While ALDH2 has been reported to be involved in monoamine metabolism in the liver [20] and alcohol metabolism in the brain [21], our NGS data reported upregulation of Aldh1a1 in A-treated AD-like astrocytes (Fig