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Moreover, significantly decreased glutathione level, total anti-oxidant capacity and superoxide dismutase activitywere observed in the examined tissues

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Proliferation assay 1919 isogenic cells, MDA-MB-468 BRCA PHGDH wild type cells and MDA-MB-231 BRCA cells characterized by PHGDH amplification were seeded (7500 cells/well) in 96-well plates (Sigma-Aldrich) and incubated at 37 C for 24 h to obtain optimal adherence to the surface

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Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunctions in diet-induced obese mice

However, the subgroup analysis revealed that the improvement was not significant in participants with MCI