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These cardiovascular effects suggest potential applications in ischemic heart disease, peripheral vascular disease, and vascular injury, though clinical translation requires confirmation of effects in human subjects

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This broad activity has made it an important subject of investigation in regenerative medicine, tissue engineering, sports science, and biotechnology research

39 Additionally, there is established evidence of alterations in glutamate circuits and GABAergic circuits in ASD patients, as manifested by increased numbers of excitatory synapses and spine densities, significantly reduced levels of glutamic acid decarboxylase, and GABAA and GABAB receptor alterations in the postmortem brains of patients with autism

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