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Oral drugs undergo what is known as first-pass metabolism. First-pass metabolism is when the concentration of a drug, specifically when administered orally, is significantly reduced before it reaches systemic circulation

Community sources who report irritation often describe it resolving when the concentration is lowered or application spaced out

You can use sugar substitutes but not sugar to sweeten drinks

Hypopigmentation (lightening of skin color) is a rare complication of laser hair removal and would be more common if tanned skin was treated with a non-specialized laser

doi: 10.7150/thno.42523 65 ItohGChidaSYanagiharaKYashiroMAibaNTanakaM

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