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To ensure consistency and reliability, all assessments at each time point will be conducted by two independent, calibrated central assessors who are blinded to treatment allocation and are not involved in any clinical aspect of the trial

A 2022 study examined the impact of enteric-coated peppermint oil capsules on the gut microbiota composition in children aged 7-12 years with functional abdominal pain

Always wear gloves when handling the capsules to avoid contamination and degradation from skin oils

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Use sterile water only if specified or in unique protocols