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10.1016/j.toxlet.2011.11.030 91 WangX.PengP.PanZ.FangZ.LuW.LiuX

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Any improvements driven by weight loss and better insulin sensitivity may fade if weight is regained

This reduction may theoretically lessen inflammation and oxidative stress in impacted tissues

In this review, we summarized the vital signaling pathways and discussed the current potential therapeutic targets in HNSCC as well as presenting preclinical animal models and ongoing or completed clinical studies about targeted therapy, which may contribute to a more favorable prognosis of HNSCC