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Mianserin increases the amount of extracellular dopamine in the prefrontal cortex by antagonizing somatodentritic and pre-synaptic 2 -adrenorecptors, which function as inhibitory autoreceptors and heteroreceptors and lead to the disinhibition of dopamine receptors (Gilsbach and Hein, 2012

A comparative study with respect to buprenorphine

Isolation of primary hepatocytes Mice were anesthetized and perfused with prewarmed 37 C Hanks buffer (Beyotime, C0218) and 0.05% collagenase IV (Sigma, C-5138) via hepatic portal vein