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111 In-labeled minigastrin (LEEEEEAYGWMDF), a CCK-2 receptor-selective peptide, has been employed to treat human colorectal and pancreatic tumors 70

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However, Grk2 deficiency in global adult hemizygous mice does not cause hypertension but impairs the increase in blood pressure and prevents vascular remodeling secondary to Ang II infusion [31]

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Over-dosing means unnecessary side effects, potentially severe ones like nausea, vomiting, or the kind of gastrointestinal issues that make people quit their protocol entirely