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Ultimately, implementation of immune-augmenting nutritional supplements within breast cancer care may require personalized approaches taking into consideration tumour subtype, underlying immunologic competency/deficiency, previous treatments received, microbiome profile and comorbid autoimmunity as well as multidisciplinary teamwork to translate promising immunobiologic signals into safe and empirically defined adjuncts to conventional anticancer immunity that are additive rather than counterproductive to patient health (197)

The physiological adaptations over time need to be considered

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Krivic, A., Majerovic, M., Jelic, I., Seiwerth, S., & Sikiric, P

This positions it as a key mediator of mitochondrial-to-nuclear communication, giving it a unique role in regulating how cells respond to metabolic stress, exercise, and ageing

van Erp et al