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Acknowledgements The present study was supported by the Research Council of Norway [grant number: 214329]

The C-terminal TMD plays a critical role in directing Bnip3 to the mitochondria, facilitating homodimer formation, and enabling its proapoptotic functions (Chen et al., 1997

Over time, ROS levels exceed antioxidant defense, which promotes increased collagen-degrading MMP production

The ratio of Nrf2-ARE binding to Keap1 content also illustrates the relationship between Keap1 protein and Nrf2-ARE binding

Dndar and Bush 2009

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death