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10.1016/j.jhep.2011.02.011 58 GongM

Others need more time and a more disciplined routine before they can tell what is working

Current studies have demonstrated that inhibiting various steps of TMAO production can reduce TMAO levels and treat AS ( Figure 2 )

The American Academy of Family Physicians and NIH identify the following clinical manifestations: Fatigue and generalized weakness Megaloblastic anemia (abnormally large, immature red blood cells) Tingling or numbness in the hands and feet (peripheral neuropathy) Difficulty walking and balance problems Cognitive disturbances including memory difficulty and confusion Mood changes, including depression and irritability Glossitis (swollen, inflamed tongue) Early symptoms such as fatigue and mild tingling are often attributed to stress, aging, or other conditions

The typical manifestations of photoaged skin include a leather-like appearance in areas exposed to UV light, characterized by dense localized wrinkles along with common pigmentation spots and erythema (3, 4)

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