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If the individual has significant accumulation (older age, chronic disease, prior chemotherapy), the first course may produce the most noticeable effects Subsequent courses: Target newly accumulated senescent cells

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479 Studies have shown that OIT for IgE-mediated FA desensitizes patients who are at risk or have experienced severe allergies to peanuts, eggs and milk

That means the default pathway to market is the same gauntlet every pharmaceutical faces: preclinical studies, Investigational New Drug (IND) applications, phased clinical trials, and a New Drug Application (NDA) (or an Abbreviated New Drug Application (ANDA) for generics)