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Over recent years two trials with nerve growth factor (NGF) designed to protect forebrain cholinergic neurons (early to moderate stage AD patients) were terminated after phase I [15,16] (NCT00017940, NCT00876863)

A number of the rare SCN9A variants resulted in gain of function of Na v 1.7, owing to impaired inactivation, following expression in HEK cells 112

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USA 114 , 28072812 (2017)

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This was accompanied by hypomethylation of the lactoferrin gene promoter region in the adult uterus (Li et al., 1997), however no such pattern of methylation was detected when the animals were subjected to the same period during adulthood