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PMID: 33996490

The beta-lactam antibiotic, ceftriaxone, dramatically improves survival, increases glutamate uptake and induces neurotrophins in stroke

doi: 10.1016/j.pmrj.2017.04.016 28 MooneyJ

[Interesting fact treatment of OTC deficiency made headlines in 1999 when Jamie Gelsinger, an 18-year-old with mild OTC deficiency died during a gene therapy trial

Cell viability assays showed that blocking Tspo prior to pharmacologic GPX4 inhibition, but not co-treatment, significantly reduced sensitivity to ferroptosis in dose-dependent manner, with almost complete rescue of cell death at 10 M PK11195 (Fig

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