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Colon-targeted KPV study Demonstrated that oral, colon-specific KPV therapy effectively reduced inflammation in preclinical models of inflammatory bowel disease

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Lopez A, Harada K, Chen HC, Bhutani MS, Weston B, Lee JH, Maru DM, Chin FW, Rogers JE, Thomas I, Amlashi FG, Blum-Murphy MA, Rice DC , Zhao M, Hofstetter WL, Nguyen Q, Ajani JA

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RNA sequencing of giredestrant and palbociclib treated cells, and proteomic analysis of palbociclib treated cells identified pathways consistent with oxidative stress and increased lipid peroxidation (Fig