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It also indicates that hypomagnesemia may occur within 1 year of PPI therapy initiation and can have serious clinical consequences[227] At present the mechanism of the PPI-induced low magnesium levels is not known

Dupilumab is also associated with an increased risk of oral herpes (cold sores)

Psychiatry, 13 , 611616

Observational studies A large number of cross-sectional and prospective cohort studies have associated elevated blood homocysteine concentrations with measures of poor cognitive scores and increased risk of dementia, including Alzheimer's disease (reviewed in 67, 69)