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doi:10.1186/s12964-023-01364-1 Hao Z, Guo S, Tu W, et al

In 2004, through the high throughput screening to find two potential thiophenecarboxamides 110 and 111 ( Figure 23 ), Baxter et al

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It has been reported that taVNS may inhibit peripheral inflammatory responses by modulating the 7nAChR/JAK2/STAT3 signaling pathway in the spleen, reducing the release of chemokine C-X-C Motif Chemokine Ligand 1 (CXCL1) and exerting anti-inflammatory effects, thereby improving LPS-induced depressive-like behaviors in rats (105)

The key insight for patients: this field has moved from having zero approved liver-specific therapies to having two within 18 months

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