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TGF-1 promotes collagen synthesis through the following mechanisms, as determined by an examination of its mechanistic contribution to chronic kidney diseases and idiopathic pulmonary fibrosis: (i) activation of downstream signalling pathways, including the TGF-1/Smad pathway

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For individuals with insulin resistance and DM, the viewpoint of Corona et al indicates that metformin, glucagon-like peptide-1 agonist, and sodium-glucose cotransporter-2 inhibitor are more effective in improving ED [167]