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Increased formation of methylglyoxal and protein glycation, oxidation and nitrosation in triosephosphate isomerase deficiency

Altogether, while anxiety-like behaviors are prevalent across various AD models, the onset age, severity, and sex dependence vary greatly

Michael et al, 2023)

The follow-up time of various RCTs is different to some extent. In addition, the trials differed in enrollment criteria, treatment protocols, follow-up duration, and primary outcome measures, making direct comparisons challenging