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Yildirim M, Colak A, Col M, Canakci S (2009) A new recombinant phosphotriesterase homology protein from Geobacillus caldoxylosilyticus TK4: an extremely thermo- and pH-stable esterase

Only small, highly lipophilic molecules can passively diffuse across the barrier (Maiuolo et al., 2018)

Anemia improvement in 4.2 / mice treated with mitapivat was associated with a significant reduction in spleen to BW ratio (Supplemental Figure 4, A and B) and decreased spleen iron content (Supplemental Figure 4B)