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Safety and Side Effects of B12 Supplements in Pregnancy Vitamin B12 supplementation is generally considered safe during pregnancy, with a good safety profile established through extensive clinical use

For Vitamin D, the serum 25-hydroxyvitamin D test is recommended

Parenteral administration of thiamine has resulted in anaphylactic shock

After 21 days at room temperature, the medication should be discarded regardless of the printed expiration date

Unlike commercially manufactured medications, compounded drugs are mixed in smaller batches and may not undergo the same long-term stability testing as brand-name drugs

[4] [6] The concern about B12 keeping people awake likely stems from its role in energy production