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In vivo studies reported that out of more than 20 known isoforms of claudins, the absence of claudin-5 and claudin-3 lead to loss of BBB integrity and barrier disruption, which, in turn, disturbs the proper functioning of BBB [1, 21, 22]

The activation of these defense mechanisms varies significantly among plant species ( Table 8 )

Huang, L., Chen, J

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By definition, antioxidants represent molecules capable of inhibiting or quenching free radical reactions and delaying or preventing cell damage, and, in lower concentration than potential substrate which might be oxidized, significantly delay or hinder its oxidation (Nimse and Pal, 2015