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For example, the activation of inflammasomes, especially the NLRP3 inflammasome, leads to endothelial dysfunction, plaque formation, and myocardial injury by inducing the release of pro-inflammatory cytokines such as IL-1, IL-18, and IL-6 ( 5.1 The anti-inflammatory effect in atherosclerosis Silybin has been shown to reduce the inflammatory response in atherosclerotic lesions, with its core mechanism involving the direct inhibition of key pro-inflammatory signaling pathways

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This abundance of oxidative stress is the precursor to disease, sickness, and many other effects on the body, from low energy to aging skin

Similarly, the repurposing of anti-inflammatory agents such as aspirin has demonstrated preclinical efficacy in preserving DA neurons [298]

The two CCG domains coordinate a linear [3Fe-4S] cluster (cluster D1) and a noncubane [4Fe-4S] cluster (cluster D2) (Fig