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Genetic factors to consider include: Mutations in the MTHFR gene, which can affect folate and B12 metabolism Variations in genes involved in B12 transport and utilization Understanding these factors helps doctors give better care

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Previous studies [9, 10] have demonstrated that oral folinic acid, oral trimethylglycine, and subcutaneous injections of methyl Vitamin B12 were able to greatly improve methylation, glutathione, and oxidative stress, similar to the results here

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The dynamic roles of advanced glycation endproducts