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Liu X, Newton R C and Scherle P A (2010) Developing Met pathway inhibitors for cancer therapy: progress and challenges

FDA's Official Reasons: Lack of Clinical Trials: The FDA emphasizes the need for extensive, controlled clinical trials, which are currently lacking

Commonly Reported Effects The most frequently mentioned side effect is next-morning fatigue or grogginess, typically reported when doses exceed individual tolerance or timing is off

BMC Med 14, 103 (2016).

The link is clear: a compromised gut barrier (leaky gut) allows inflammatory cytokines and lipopolysaccharides (LPS) to enter systemic circulation

Hypothermia happens when the body loses heat faster than it can produce it, causing the core temperature to drop below 35C (95F)