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Collectively, the apoE4 variant appears to be associated with low cholesterol and poor lipidation, which, together with domain interactions, decreases its stability leading to impaired neuronal lipid metabolism and changes in lipidome profile that alters the brain innate immunity response to AD pathologies

As the researchers report, there are several avenues where human endothelial cells employ different pathways from the elephant seals, presumably reflecting the lack of adaptation to routinely coping with hypoxia

Acknowledgments We are thankful to Biorender.com for helping us draw the figures

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C., Howarth, C